Director of DMPK

Discovery · Great Abington, Cambridgeshire
Department Discovery
Employment Type Full-Time
Minimum Experience Senior Manager/Supervisor


Amphista Therapeutics is a fast-growing Cambridge-based biotech and the leading European Targeted Protein Degradation (TPD) company. Our unique scientific approach to TPD, one of the hottest areas in modern drug discovery, gives us a range of advantages over other therapeutic strategies. In addition to an oversubscribed $53M funding round in 2021. We were delighted to recently announce two separate collaboration deals with Bristol Myers Squibb and Merck Healthcare which will allow us to grow and advance our therapeutic portfolio even faster. Initially founded from the laboratory of Professor Alessio Ciulli (University of Dundee) our team comprises both academic and drug discovery pioneers of the TPD field and a growing R&D team focused on advancing a portfolio of medicines to the clinic using our proprietary next generation TPD technologies.


As a key part of Amphista R&D leadership, you’ll work closely with the VP of Drug Discovery as well as chemistry, biology, pharmacology and development leaders as well as senior leadership including CSO, CEO and others. This is an exciting opportunity to join a fast growing and dynamic company operating at the cutting edge of one of the most transformational recent developments in drug discovery strategies to develop first in class and best in class medicines.


The successful candidate will lead and contribute to Amphista’s protein degrader drug discovery and development programs and have a significant impact on the success of the company and R&D strategy.


Leading and working within project and functional teams, you’ll help drive project advancement and decisions from the lead identification and optimisation phases through to candidate selection and development across the Amphista portfolio.

Responsibilities include:

  • Responsible for driving and developing specific discovery programs, scientific strategy and workstreams to ensure that the IP position of the platform and portfolio is developed to develop Amphista’s leadership position and unique IP estate.
  • Highly scientifically creative and flexible as evidenced by successful delivery of multiple projects including “non-standard” projects (eg agonists, covalent modifiers, bifunctionals, less common dosing regimens & routes).
  • Contributing to R&D strategy.
  • Working in a fast-moving drug discovery environment, contributing to successful delivery of multiple projects in parallel.
  • Responsible for leading, developing and introducing new strategies and ways to advance specific projects or systems.
  • Maintain good awareness of the internal & external developments in the field, apply these to each project, and proactively suggest and evaluate new techniques.
  • Design and implement new ways of working that have a direct impact on data quality & productivity.

Education / Experience:

  • Degree or PhD in Biology, Pharmacy, Pharmacokinetics or related pharmaceutical science.
  • Successful leadership of teams to achieve significant project milestones and to develop team members.
  • Experience of managing and leading a technical team or team of Research Biologists.
  • Demonstrated excellence in independently planning and executing experiments as well as critical data analysis skills.
  • Significant experience and a proven track record of supporting small molecule drug discovery and development programs or relevant industry experience.
  • Awareness of commercial environment and opportunities in therapeutic areas

Thank You

Your application was submitted successfully.

  • Location
    Great Abington, Cambridgeshire
  • Department
  • Employment Type
  • Minimum Experience
    Senior Manager/Supervisor